Outputs (26)

Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study (2023)
Journal Article

Background and objectives: There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this... Read More about Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study.

The impact of proctored online assessments on academic attainment, student experience and wellbeing (2023)
Presentation / Conference
Jones, M., Namvar, S., Miklavc, P., Smyth, L., & Ferry, N. (2023, September). The impact of proctored online assessments on academic attainment, student experience and wellbeing. Poster presented at LTEC Festival of Learning and Teaching 2023, University of Salford, UK

Online assessment is a widely utilised strategy for higher education assessment due to its numerous benefits for universities, academic staff, and students alike. However, it has been highlighted within the wider sector that this approach leads to gr... Read More about The impact of proctored online assessments on academic attainment, student experience and wellbeing.

Alterations in Autophagy Marker Distribution in Different Genetic Subtypes of Frontotemporal Lobar Degeneration (2023)
Thesis

Frontotemporal dementia (FTD) is the second most common type of early-onset dementia and is characterised by impairments in language and behavioural changes whilst memory is normally well preserved; it can be clinically subdivided into behavioural va... Read More about Alterations in Autophagy Marker Distribution in Different Genetic Subtypes of Frontotemporal Lobar Degeneration.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease (2017)
Journal Article
allergic fungal disease. Journal of Allergy and Clinical Immunology, 142(2), 407-414. https://doi.org/10.1016/j.jaci.2017.09.039

Background
Allergic diseases caused by fungi are common. The best understood conditions are allergic
bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS).
Our knowledge of the fungal microbiome (mycobiome) is li... Read More about Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

The effects of corticosteroids on cytokine production from asthma lung lymphocytes (2014)
Journal Article
Kaur, M., Reynolds, S., Smyth, L., Simpson, K., Hall, S., & Singh, D. (2014). The effects of corticosteroids on cytokine production from asthma lung lymphocytes. International Immunopharmacology, 23(2), 581-4. https://doi.org/10.1016/j.intimp.2014.10.008

BACKGROUND

Lymphocytes play a central role in the pathophysiology of asthma. Corticosteroids have a limited effect in severe asthma and we hypothesise that lymphocytes play a central role in corticosteroid insensitivity. We investigated the effect... Read More about The effects of corticosteroids on cytokine production from asthma lung lymphocytes.

Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article
Smyth, L., Eustace, A., Kolsum, U., Blaikely, J., & Singh, D. (2010). Increased airway T regulatory cells in asthmatic subjects. Chest, 138(4), 905-912. https://doi.org/10.1378/chest.09-3079

Background: T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased in patients with more severe asthma. We also investigated the regulatory functio... Read More about Increased airway T regulatory cells in asthmatic subjects.

Reply to comment on chest-10-1440 : Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article

Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients (2010)
Journal Article
Eustace, A., Smyth, L., Mitchell, L., Williamson, K., Plumb, J., & Singh, D. (2010). Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients. Chest, https://doi.org/10.1378/chest.10-0779

Background: Lymphocytes secrete IL-17A and IL-17F which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of COPD patients... Read More about Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients.