Outputs (36)

Investigation of P53 and TTC5 function in lung cancer (2024)
Thesis

Lung cancer represents 11.6% of the total cases with patients destined for a poor outcome due to late-stage detection, therefore it is important to find new approaches to detect and treat this disease. Current evidence suggests a role of p53 gene and... Read More about Investigation of P53 and TTC5 function in lung cancer.

Targeting Transcriptional CDKs in Medulloblastoma (2024)
Thesis

Medulloblastoma (MB) is the most common malignant tumour of the brain in children. Current treatments include surgery, radiotherapy and chemotherapy. Although the five-year survival rate is over 70%, the treatment is exceptionally aggressive, leaving... Read More about Targeting Transcriptional CDKs in Medulloblastoma.

Evaluation of Novel Diketones as Anti-cancer Agents (2024)
Thesis

Recent studies indicated high levels of cytotoxicity of dibenzoylmethane (DBM) and its derivatives on some mammalian cancer cells. On the other hand, p53 tumour suppressor is a DNA damage inducible transcription factor mutated in over half of human c... Read More about Evaluation of Novel Diketones as Anti-cancer Agents.

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma (2023)
Journal Article
Pentimalli, F., Krstic- Demonacos, M., Costa, C., Mutti, L., & Bakker, E. (2023). Intratumor microbiota as a novel potential prognostic indicator in mesothelioma. Frontiers in Immunology, 14, https://doi.org/10.3389/fimmu.2023.1129513

Introduction: Despite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to... Read More about Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA (2022)
Journal Article

In this study, the efficiency of RNA interference of small interfering RNAs (siRNAs) bearing 5′-O-methyl-2′-deoxythymidine (X) and 5′-amino-2′, 5′-dideoxythymidine (Z) at the 5′-end of the sense strand and the antisense strand of siRNA was investigat... Read More about Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA.

Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma (2022)
Journal Article

Importance: Some recently proposed frontline therapies for malignant pleural mesothelioma (MPM) are very costly, yet their impact on quality of life and overall survival of these patients remains arguable. Given the high social toll of this aggressiv... Read More about Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma.

Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies (2022)
Journal Article
Bakker, E., Fujii, M., Krstic‑Demonacos, M., Demonacos, C., & Alhammad, R. (2022). Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies. International Journal of Oncology, 60(2), 16. https://doi.org/10.3892/ijo.2022.5306

The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear factor erythroid 2‑like 2 (NRF2) and regulates the protein stability... Read More about Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies.

Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer (2021)
Journal Article

Mutations in the p53 tumor suppressor are found in over 50% of cancers. p53 function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated the posttranslationally modified p53, including p53 a... Read More about Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer.

Is there already a need of reckoning on cancer immunotherapy? (2021)
Journal Article
Correale, P., Pentimalli, F., Baglio, G., Krstic- Demonacos, M., Saladino, R., Giordano, A., & Mutti, L. (2021). Is there already a need of reckoning on cancer immunotherapy?. Frontiers in Pharmacology, 12, 638279. https://doi.org/10.3389/fphar.2021.638279

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.