Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases
(2003)
Journal Article
Karahalil, B., de Souza-Pinto, N., Parsons, J., Elder, R., & Bohr, V. (2003). Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. Journal of Biological Chemistry, 278(36), 33701-7. https://doi.org/10.1074/jbc.M301617200
Mitochondrial DNA is constantly exposed to high levels of endogenously produced reactive oxygen species, resulting in elevated levels of oxidative damaged DNA bases. A large spectrum of DNA base alterations can be detected after oxidative stress, and... Read More about Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.