Outputs (431)

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy (2017)
Journal Article
implications for optimizing anti-angiogenic therapy. Oncotarget, 2017(8), 56126-56142. https://doi.org/10.18632/oncotarget.18445

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypox... Read More about Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy.

Built asset management climate change adaptation model (2017)
Journal Article
Jones, K., Desai, A., Brosnan, N., Cooper, J., & Ali, F. (2017). Built asset management climate change adaptation model. International Journal of Disaster Resilience in the Built Environment, 8(3), 263-274. https://doi.org/10.1108/IJDRBE-07-2016-0032

Climate change continues to pose major challenges to those responsible for the management of built assets. Whilst mitigation is largely being driven by legislation and corporate social responsibility, adaptation has to compete alongside general built... Read More about Built asset management climate change adaptation model.

A wheelchair control system using human-machine interaction: single-modal and multimodal approaches (2017)
Journal Article
Shahin, M., Tharwat, A., Gaber, T., & Hassanien, A. (2017). A wheelchair control system using human-machine interaction: single-modal and multimodal approaches. Journal of Intelligent Systems, 28(1), https://doi.org/10.1515/jisys-2017-0085

Recent research studies showed that brain-controlled systems/devices are breakthrough technology. Such devices can provide disabled people with the power to control the movement of the wheelchair using different signals (e.g. EEG signals, head moveme... Read More about A wheelchair control system using human-machine interaction: single-modal and multimodal approaches.

Clang, chitter, crunch : perceptual organisation of onomatopoeia (2017)
Journal Article
Bones, O., Davies, W., & Cox, T. (2017). Clang, chitter, crunch : perceptual organisation of onomatopoeia. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3694-3694. https://doi.org/10.1121/1.4988048

A method has been developed that utilizes a sound-sorting and labeling procedure, with correspondence analysis of participant-generated descriptive terms, to elicit perceptual categories of sound. Unlike many other methods for identifying perceptual... Read More about Clang, chitter, crunch : perceptual organisation of onomatopoeia.

A user-centered taxonomy of factors contributing to the listener experience of reproduced audio (2017)
Journal Article
Woodcock, J., Davies, W., & Cox, T. (2017). A user-centered taxonomy of factors contributing to the listener experience of reproduced audio. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3464-3464. https://doi.org/10.1121/1.4987193

The traditional paradigm for the assessment of audio quality is that of a listener positioned in the geometric center of a standardized loudspeaker setup, fully attending to the reproduced sound scene. However, this is not how listeners generally int... Read More about A user-centered taxonomy of factors contributing to the listener experience of reproduced audio.

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism (2017)
Journal Article
De Santi, C., Melaiu, O., Bonotti, A., Cascione, L., Di Leva, G., Foddis, R., …Landi, S. (2017). Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism. Scientific reports, 7(2017), #3140. https://doi.org/10.1038/s41598-017-02694-0

Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key-role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathwa... Read More about Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism.

Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan (2017)
Journal Article
van Kesteren, F., Mastin, A., Torgerson, P., Mytynova, B., & Craig, P. (2017). Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan. Parasitology, 144(10), 1328-1337. https://doi.org/10.1017/S0031182017000397

Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan. In 2012, an echinococcosis control scheme was started that included dosing owned dogs in the Alay Valley, Kyrgyzstan with praziquantel. Control programmes require large investments of mo... Read More about Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan.

Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) (2017)
Journal Article
De Francesco, E., Bonuccelli, G., Maggiolini, M., Sotgia, F., & Lisanti, M. (2017). Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Oncotarget, 2017(8), 67269-67286. https://doi.org/10.18632/oncotarget.18428

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by... Read More about Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

Influence of source location and temporal structure on spatial auditory saliency (2017)
Journal Article
Podwinska, Z., Fazenda, B., & Davies, W. (2017). Influence of source location and temporal structure on spatial auditory saliency. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3639-3639. https://doi.org/10.1121/1.4987852

Hitherto, not many studies have dealt with spatial auditory saliency. Auditory attention studies concerned with spatial aspects generally concentrate on top-down selective or divided attention, e.g., where subjects are asked to attend to one source a... Read More about Influence of source location and temporal structure on spatial auditory saliency.

Differences in sound perception are reflected by individual auditory fingerprints in musicians (2017)
Journal Article
Benner, J., Reinhardt, J., Hofmann, E., Stippich, C., Schneider, P., Blatow, M., & Davies, W. (2017). Differences in sound perception are reflected by individual auditory fingerprints in musicians. ˜The œJournal of the Acoustical Society of America (Online), 141(5), 3818-3818. https://doi.org/10.1121/1.4988456

Musicians have been reported to show significant inter-Individual differences in elementary hearing functions, sound perception mode, musical instrument preference, performance style, as well as more complex musical abilities like absolute- and relat... Read More about Differences in sound perception are reflected by individual auditory fingerprints in musicians.