Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
(2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Merkert, E., Terrinoni, A., Vousden, K., …Sayan, B. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), https://doi.org/10.1073/pnas.1110977109
p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.