Outputs (17)

Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy (2017)
Journal Article
Ozsvari, B., Bonuccelli, G., Sanchez-Alvarez, R., Foster, R., Sotgia, F., & Lisanti, M. (2017). Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy. Aging, 9(12), 2610-2628. https://doi.org/10.18632/aging.101351

Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side... Read More about Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy.

G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts (2017)
Journal Article
De Francesco, E., Sotgia, F., Clarke, R., Lisanti, M., & Maggiolini, M. (2017). G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts. International Journal of Molecular Sciences, 18(12), https://doi.org/10.3390/ijms18122713

G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive... Read More about G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts.

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment (2017)
Journal Article
De Francesco, E., Sims, A., Maggiolini, M., Sotgia, F., Lisanti, M., & Clarke, R. (2017). GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment. Breast Cancer Research, 19(1), 129. https://doi.org/10.1186/s13058-017-0923-5

The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional ta... Read More about GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

A new mutation-independent approach to cancer therapy : inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis. (2017)
Journal Article
Ozsvari, B., Sotgia, F., & Lisanti, M. (2017). A new mutation-independent approach to cancer therapy : inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis. Aging, 9(10), 2098-2116. https://doi.org/10.18632/aging.101304

Here, we used MCF7 cells as a model system to interrogate how MYC/RAS co-operativity contributes to metabolic flux and stemness in breast cancer cells. We compared the behavior of isogenic MCF7 cell lines transduced with c-Myc or H-Ras (G12V), either... Read More about A new mutation-independent approach to cancer therapy : inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis..

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer (2017)
Journal Article
Monti, D., Sotgia, F., Whitaker-Menezes, D., Tuluc, M., Birbe, R., Berger, A., …Martinez-Outschoorn, U. (2017). Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Seminars in Oncology, 44(3), 226-232. https://doi.org/10.1053/j.seminoncol.2017.10.001

Background High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidativ... Read More about Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.

Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). (2017)
Journal Article
Ozsvari, B., Sotgia, F., Simmons, K., Trowbridge, R., Foster, R., & Lisanti, M. (2017). Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). Oncotarget, 8(45), 78340-78350. https://doi.org/10.18632/oncotarget.21259

Previous studies have now well-established that epithelial cancer cells can utilize ketone bodies (3-hydroxybutyrate and aceto-acetate) as mitochondrial fuels, to actively promote tumor growth and metastatic dissemination. The two critical metabolic... Read More about Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)..

Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer : companion diagnostics for cancer therapy (2017)
Journal Article
Sotgia, F., & Lisanti, M. (2017). Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer : companion diagnostics for cancer therapy. Oncotarget, 8(40), 66925-66939. https://doi.org/10.18632/oncotarget.19963

Here, we performed a systematic analysis to discover new biomarkers of overall survival and tumor progression in ovarian cancer patients. More specifically, we determined whether nuclear-encoded mitochondrial genes related to mitochondrial biogenesis... Read More about Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer : companion diagnostics for cancer therapy.

Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers : companion diagnostics for personalized medicine. (2017)
Journal Article
Sotgia, F., & Lisanti, M. (2017). Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers : companion diagnostics for personalized medicine. Oncotarget, 8(40), 67117-67128. https://doi.org/10.18632/oncotarget.19962

Here, we employed a bioinformatics approach to identify novel molecular determinants to predict tumor progression and overall survival in gastric cancer patients. In particular, we directly assessed whether nuclear-derived mRNA species encoding prote... Read More about Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers : companion diagnostics for personalized medicine..

Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients : use as companion diagnostics (2017)
Journal Article
Sotgia, F., & Lisanti, M. (2017). Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients : use as companion diagnostics. Oncotarget, 8(40), 68095-68107. https://doi.org/10.18632/oncotarget.19677

Here, we used an informatics-based approach to identify novel biomarkers of overall survival and tumor progression in non-small cell lung cancer (NSCLC) patients. We determined whether nuclear-encoded genes associated with mitochondrial biogenesis an... Read More about Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients : use as companion diagnostics.

Mitochondrial markers predict recurrence, metastasis and Tamoxifen-resistance in breast cancer patients : early detection of treatment failure with companion diagnostics (2017)
Journal Article
Sotgia, F., Fiorillo, M., & Lisanti, M. (2017). Mitochondrial markers predict recurrence, metastasis and Tamoxifen-resistance in breast cancer patients : early detection of treatment failure with companion diagnostics. Oncotarget, 2017(8), 68730-68745. https://doi.org/10.18632/oncotarget.19612

Here, we used a data-mining and informatics approach to discover new biomarkers of resistance to hormonal therapy in breast cancer. More specifically, we investigated whether nuclear-encoded genes associated with mitochondrial biogenesis can be used... Read More about Mitochondrial markers predict recurrence, metastasis and Tamoxifen-resistance in breast cancer patients : early detection of treatment failure with companion diagnostics.