Outputs (37)

Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance (2020)
Journal Article
Chung, W., Correa, E., Yoshimura, K., Chang, M., Dennison, A., Takeda, S., & Chang, Y. (2020). Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance. American Journal of Translational Research, 12(1), 171-179

A rapid blood-based diagnostic modality to detect pancreatic ductal adenocarcinoma (PDAC) with high accuracy is an unmet medical need. The study aimed to validate a unique diagnosis system using Probe Electrospray Ionization Mass Spectrometry (PESI-M... Read More about Using probe electrospray ionization mass spectrometry and machine learning for detecting pancreatic cancer with high performance.

pH plays a role in the mode of action of trimethoprim on Escherichia coli (2018)
Journal Article
AlRabiah, H., Allwood, J., Correa, E., Xu, Y., & Goodacre, R. (2018). pH plays a role in the mode of action of trimethoprim on Escherichia coli. PLoS ONE, 13(7), e0200272. https://doi.org/10.1371/journal.pone.0200272

Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L-1). Trimethoprim inhibits dihydrofolate reductase and thereby is a... Read More about pH plays a role in the mode of action of trimethoprim on Escherichia coli.

Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy (2017)
Journal Article
Ashton, L., Brewster, V., Correa, E., & Goodacre, R. (2017). Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy. Analyst, 5, https://doi.org/10.1039/C6AN02516A

In this study we demonstrate the use of Raman spectroscopy to determine protein modifications as a result of glycosylation and iron binding. Most proteins undergo some modifications after translation which can directly affect protein function. Identi... Read More about Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy.

Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS) (2016)
Journal Article
Han, T., Correa, E., Lean, M., Lee, D., O’Neill, T., Bartfai, G., …Casanueva, F. (2017). Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS). Endocrine, 55(2), 456-469. https://doi.org/10.1007/s12020-016-1135-y

Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity... Read More about Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS).

Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study (2016)
Journal Article
Overman, M., Pendleton, N., O’Neill, T., Bartfai, G., Casanueva, F., Finn, J., …Tournoy, J. (2016). Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study. European Journal of Nutrition, 56(6), 2093-2103. https://doi.org/10.1007/s00394-016-1247-4

PURPOSE: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvita... Read More about Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study.

Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols (2016)
Journal Article
AlMasoud, N., Correa, E., Trivedi, D., & Goodacre, R. (2016). Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols. Analytical Chemistry, 88(12), 6301-6308. https://doi.org/10.1021/acs.analchem.6b00512

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has successfully been used for the analysis of high molecular weight compounds, such as proteins and nucleic acids. By contrast, analysis of low molecular wei... Read More about Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols.

Data standards can boost metabolomics research, and if there is a will, there is a way (2015)
Journal Article
Rocca-Serra, P., Salek, R., Arita, M., Correa, E., Dayalan, S., Gonzalez-Beltran, A., …Neumann, S. (2016). Data standards can boost metabolomics research, and if there is a will, there is a way. Metabolomics, 12(1), https://doi.org/10.1007/s11306-015-0879-3

Thousands of articles using metabolomics approaches are published every year. With the increasing amounts of data being produced, mere description of investigations as text in manuscripts is not sufficient to enable re-use anymore: the underlying dat... Read More about Data standards can boost metabolomics research, and if there is a will, there is a way.

PTU-093 Metabolomic profiling in inflammatory bowel disease (2015)
Journal Article
Hildebrand, D., Trivedi, D., Xu, Y., Rattray, N., Ross, N., Correa, E., …Watson, A. (2015). PTU-093 Metabolomic profiling in inflammatory bowel disease. Gut, 64(Suppl), A102.1-A102. https://doi.org/10.1136/gutjnl-2015-309861.208

Introduction Inflammatory bowel disease is classified into 2 main types; Crohn’s disease (CD) and ulcerative colitis (UC). Differentiation can prove clinically challenging. Metabolomic profiling is an emerging science that is utilised for biomarker d... Read More about PTU-093 Metabolomic profiling in inflammatory bowel disease.

PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers (2015)
Journal Article
Ross, N., Correa, E., Rattray, N., Hildebrand, D., Xu, Y., Trivedi, D., …Watson, A. (2015). PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers. Gut, 64(Suppl), A300.1-A300. https://doi.org/10.1136/gutjnl-2015-309861.647

Introduction Pancreatic cancer is a devastating disease with a poor outcome. Current biomarkers fall short in accessibility, sensitivity, specificity and their ability to distinguish malignant from benign conditions. Metabolomics aims to decipher mol... Read More about PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers.

Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation (2015)
Journal Article
Senko, J., Brown, A., Correa, E., Xu, Y., AlMasoud, N., Pimblott, S., …Lloyd, J. (2015). Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation. PLoS ONE, 10(6), e0131249. https://doi.org/10.1371/journal.pone.0131249

Biogeochemical processes mediated by Fe(III)-reducing bacteria such as Shewanella oneidensis have the potential to influence the post-closure evolution of a geological disposal facility for radioactive wastes and to affect the solubility of some radi... Read More about Phenotypic Characterisation of Shewanella oneidensis MR-1 Exposed to X-Radiation.