E Candi
p63 is upstream of IKKα in epidermal development
Candi, E; Terrinoni, A; Rufini, A; Chikh, A; Lena, AM; Suzuki, Y; Sayan, BS; Knight, RA; Melino, G
Authors
A Terrinoni
A Rufini
A Chikh
AM Lena
Y Suzuki
Dr Berna Sayan B.S.Sayan@salford.ac.uk
Lecturer
RA Knight
G Melino
Abstract
The epidermis, the outer layer of the skin composed of keratinocytes, develops following the action of the transcription factor p63. The mouse Trp63 gene contains two promoters, driving the production of distinct proteins, one with an N-terminal trans-activation domain (TAp63) and one without (ΔNp63), although their relative contribution to epidermal development is not clearly established. To identify the relative role of p63 isoforms in relation to IKKα, also known to be essential for epithelial development, we performed both molecular and in vivo analyses using genetic complementation in mice. We found that the action of TAp63 is mediated at the molecular level by direct and indirect transactivation of IKKα and Ets-1, respectively. We also found that ΔNp63 upregulates IKKα indirectly, through GATA-3. Our data are consistent with a role for p63 directly upstream of IKKα in epithelial development.
Citation
Candi, E., Terrinoni, A., Rufini, A., Chikh, A., Lena, A., Suzuki, Y., …Melino, G. (2006). p63 is upstream of IKKα in epidermal development. Journal of Cell Science, 119(22), 4617-4622. https://doi.org/10.1242/jcs.03265
Journal Article Type | Article |
---|---|
Publication Date | Nov 15, 2006 |
Deposit Date | Feb 6, 2023 |
Publicly Available Date | Feb 6, 2023 |
Journal | Journal of Cell Science |
Print ISSN | 0021-9533 |
Publisher | Company of Biologists |
Volume | 119 |
Issue | 22 |
Pages | 4617-4622 |
DOI | https://doi.org/10.1242/jcs.03265 |
Publisher URL | https://doi.org/10.1242/jcs.03265 |
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