The microRNA and p53 families join forces against cancer

Barlev, NA; Sayan, BS; Candi, E; Okorokov, AL

Abstract

The product of the TP53 gene, p53, is one of the most recognised and extensively studied molecules that protects multicellular organisms from cancer. The well-deserved fame of p53 stems from the nature of its function – to coordinate an appropriate cellular response to various forms of genotoxic stress through cell cycle arrest, senescence and/or apoptosis. Given the importance of this role, it is not, perhaps, surprising that p53 was found to be inactive in more than half of human cancers. It should be noted that p53 does not work alone but cooperates with two ancestral proteins of the same family, p63 and p73. Aiming to broaden our understanding of the function of the p53 family of proteins in cancer, the mini-symposium held in the University of Leicester provided an opportunity for scientists and clinicians to exchange knowledge and expertise and to establish new collaborations. The main focus of this event was on the recently emerged link between the p53 family members and microRNA during cancer development.

Citation

Barlev, N., Sayan, B., Candi, E., & Okorokov, A. (2010). The microRNA and p53 families join forces against cancer. Cell Death and Differentiation, 17, 373-375. https://doi.org/10.1038/cdd.2009.73

• Journal Article Type: Article
• Online Publication Date: Jan 11, 2010
• Publication Date: Jan 11, 2010
• Deposit Date: Feb 6, 2023
• Publicly Available Date: Feb 6, 2023
• Journal: Cell Death and Differentiation
• Print ISSN: 1350-9047
• Publisher: Nature Publishing Group
• Volume: 17
• Pages: 373-375
• DOI: https://doi.org/10.1038/cdd.2009.73
• Publisher URL: https://doi.org/10.1038/cdd.2009.73