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p73: a multifunctional protein in neurobiology

Killick, R; Niklison-Chirou, M; Tomasini, R; Bano, D; Rufini, A; Grespi, F; Velletri, T; Tucci, P; Sayan, BS; et, al

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Authors

R Killick

M Niklison-Chirou

R Tomasini

D Bano

A Rufini

F Grespi

T Velletri

P Tucci

al et



Abstract

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, ΔNp73 shows a survival function in mature cortical neurons as selective ΔNp73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer’s disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration.

Citation

Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., …et, A. (2011). p73: a multifunctional protein in neurobiology. Molecular Neurobiology, 43, 139-146. https://doi.org/10.1007/s12035-011-8172-6

Journal Article Type Article
Online Publication Date Mar 8, 2011
Publication Date Mar 8, 2011
Deposit Date Feb 6, 2023
Publicly Available Date Feb 6, 2023
Journal Molecular Neurobiology
Print ISSN 0893-7648
Electronic ISSN 1559-1182
Publisher Springer Verlag
Volume 43
Pages 139-146
DOI https://doi.org/10.1007/s12035-011-8172-6
Publisher URL https://doi.org/10.1007/s12035-011-8172-6

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