MicroRNA control of invasion and metastasis pathways

Sreekumar, R; Sayan, BS; Mirnezami, AH; Sayan, AE

doi:10.3389/fgene.2011.00058

MicroRNA control of invasion and metastasis pathways

Sreekumar, R; Sayan, BS; Mirnezami, AH; Sayan, AE

Authors

R Sreekumar

Dr Berna Sayan B.S.Sayan@salford.ac.uk
Lecturer

AH Mirnezami

AE Sayan

Abstract

Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastases at diagnosis. This fact highlights the importance of therapeutic approaches targeting cellular invasion and metastasis programs as the next step in cancer treatment. During carcinoma progression a process called epithelial–mesenchymal transition (EMT) results in enhanced invasion and motility which is directly linked with loss of epithelial polarity and epithelial junctions, migration permissive cytoskeleton alterations, and the acquisition of mesenchymal properties. The recent discovery of microRNAs (miRNAs) controlling key cellular pathways has opened a new era in understanding how EMT pathways are modulated. In this review, we classify EMT regulating proteins according to their cellular localization (membrane, cytoplasmic, and nuclear), and summarize the current knowledge on how they are controlled by miRNAs and propose potential miRNAs for the transcripts that may control their expression.

Citation

Sreekumar, R., Sayan, B., Mirnezami, A., & Sayan, A. (2011). MicroRNA control of invasion and metastasis pathways. Frontiers in Genetics, 2, https://doi.org/10.3389/fgene.2011.00058

Journal Article Type	Article
Online Publication Date	Sep 5, 2011
Publication Date	Sep 5, 2011
Deposit Date	Feb 7, 2023
Publicly Available Date	Feb 7, 2023
Journal	Frontiers in Genetics
Publisher	Frontiers Media
Volume	2
DOI	https://doi.org/10.3389/fgene.2011.00058
Publisher URL	https://doi.org/10.3389/fgene.2011.00058