M Alahdal
Promising use of immune cell‐derived exosomes in the treatment of SARS‐CoV‐2 infections
Alahdal, M; Elkord, E
Authors
E Elkord
Abstract
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is persistently threatening the lives of thousands of individuals globally. It triggers pulmonary oedema, driving to dyspnoea and lung failure. Viral infectivity of coronavirus disease 2019 (COVID‐19) is a genuine challenge due to the mutagenic genome and mysterious immune‐pathophysiology. Early reports highlighted that extracellular vesicles (exosomes, Exos) work to enhance COVID‐19 progression by mediating viral transmission, replication and mutations. Furthermore, recent studies revealed that Exos derived from immune cells play an essential role in the promotion of immune cell exhaustion by transferring regulatory lncRNAs and miRNAs from exhausted cells to the active cells. Fortunately, there are great chances to modulate the immune functions of Exos towards a sustained repression of COVID‐19. Engineered Exos hold promising immunotherapeutic opportunities for remodelling cytotoxic T cells’ function. Immune cell‐derived Exos may trigger a stable epigenetic repression of viral infectivity, restore functional cytokine‐producing T cells and rebalance immune response in severe infections by inducing functional T regulatory cells (Tregs). This review introduces a view on the current outcomes of immunopathology, and immunotherapeutic applications of immune cell‐derived Exos in COVID‐19, besides new perspectives to develop novel patterns of engineered Exos triggering novel anti‐SARS‐CoV‐2 immune responses.
Citation
Alahdal, M., & Elkord, E. (2022). Promising use of immune cell‐derived exosomes in the treatment of SARS‐CoV‐2 infections. Clinical and Translational Medicine, 12(8), https://doi.org/10.1002/ctm2.1026
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 8, 2022 |
Publication Date | Aug 21, 2022 |
Deposit Date | Sep 6, 2022 |
Publicly Available Date | Sep 6, 2022 |
Journal | Clinical and Translational Medicine |
Publisher | Springer Verlag |
Volume | 12 |
Issue | 8 |
DOI | https://doi.org/10.1002/ctm2.1026 |
Publisher URL | https://doi.org/10.1002/ctm2.1026 |
Files
Published Version
(3.4 Mb)
PDF
Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Downloadable Citations
About USIR
Administrator e-mail: library-research@salford.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search