Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii

Gao, J-M; Yi, S-Q; Geng, G-Q; Xu, Z-S; Hide, G; Lun, Z-R; Lai, D-H

Abstract

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis
being largely influenced by the host immune status. As important epidemiological
hosts, rodents are globally distributed and are also commonly found infected with
haemoflagellates, such as those in the genus Trypanosoma. We here address whether
and how co-infection with trypanosomes can influence T. gondii infection in
laboratory models. Rats of five strains, co-infected with T. lewisi, and mice of four
strains, co-infected with T. musculi, were found to be more or less susceptible to T.
gondii infection, respectively, with corresponding increased or decreased brain cyst
burdens. Down-regulation of iNOS expression and decreased NO production or
reverse were observed in the peritoneal macrophages of rats or mice, infected with
trypanosomes, respectively. Trypanosoma lewisi and T. musculi can modulate host
immune responses, either by enhancement or suppression, and influence the outcome
of Toxoplasma infection.

Citation

Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

• Journal Article Type: Article
• Acceptance Date: Jan 20, 2021
• Online Publication Date: Feb 4, 2021
• Publication Date: May 1, 2021
• Deposit Date: Feb 18, 2021
• Publicly Available Date: Aug 4, 2021
• Journal: Parasitology
• Print ISSN: 0031-1820
• Electronic ISSN: 1469-8161
• Publisher: Cambridge University Press (CUP)
• Volume: 148
• Issue: 6
• Pages: 703-711
• DOI: https://doi.org/10.1017/S0031182021000196
• Publisher URL: https://doi.org/10.1017/S0031182021000196
• Related Public URLs: http://journals.cambridge.org/action/displayJournal?jid=PAR
• Additional Information: Additional Information : ** From PubMed via Jisc Publications Router **Journal IDs: eissn 1469-8161 **Article IDs: pubmed: 33536085; pii: S0031182021000196 **History: published 04-02-2021; Funders : National Science and Technology Major Project of China;National Natural Science Foundation of China;Natural Sciences Foundation of Guangdong Province; Grant Number: 2018ZX10101002-001 and 2018ZX10101002; Grant Number: 31720103918 and 31672276 and 31772445; Grant Number: 2016A030306048