Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition

De Santis, F; Fucà, G; Schadendorf, D; Mantovani, A; Magnani, L; Lisanti, MP; Pettitt, S; Bellone, M; Del Sal, G; Minucci, S; Eggermont, A; Bruzzi, P; Bicciato, S; Conte, P; Noberini, R; Hiscott, J; De Braud, F; Del Vecchio, M; Di Nicola, M

Abstract

During the Tenth Edition of the Annual Congress on “Anticancer Innovative Therapy” [Milan, 23/24 January 2020], experts in the fields of immuno-oncology, epigenetics, tumor cell signaling, and cancer metabolism shared their latest knowledge on the roles of i] epigenetics, and in particular, chromatin modifiers, ii] cancer metabolism, iii] cancer stem cells [CSCs], iv] tumor cell signaling, and iv] the immune system. The novel therapeutic approaches presented included epigenetic drugs, cell cycle inhibitors combined with ICB, antibiotics and other off-label drugs, small-molecules active against CSCs, liposome-delivered miRNAs, tumor-specific CAR-T cells, and T-cell–based immunotherapy. Moreover, important evidence on possible mechanisms of resistance to these innovative therapies were also discussed, in particular with respect to resistance to ICB. Overall, this conference provided scientists and clinicians with a broad overview of future challenges and hopes to improve cancer treatment reasonably in the medium-short term.

• Journal Article Type: Article
• Acceptance Date: Feb 9, 2021
• Online Publication Date: Feb 14, 2021
• Publication Date: Jun 1, 2021
• Deposit Date: Feb 17, 2021
• Publicly Available Date: Feb 14, 2022
• Journal: Cytokine & Growth Factor Reviews
• Print ISSN: 1359-6101
• Publisher: Elsevier
• Volume: 59
• Pages: 1-8
• DOI: https://doi.org/10.1016/j.cytogfr.2021.02.001
• Publisher URL: https://doi.org/10.1016/j.cytogfr.2021.02.001
• Related Public URLs: http://www.journals.elsevier.com/cytokine-and-growth-factor-reviews/
• Additional Information: Additional Information : ** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised. **Journal IDs: issn 13596101 **History: issue date 14-02-2021; accepted 09-02-2021