Prof Niroshini Nirmalan N.J.Nirmalan@salford.ac.uk
HANS Director (Interim)
Hormonal control of metabolism : regulation of plasma glucose
Nirmalan, NJ; Nirmalan, M
Authors
M Nirmalan
Abstract
Blood glucose concentrations are required to be maintained within a narrow therapeutic range in order to ensure the normal functioning of the body. This is accomplished through a complex, interactive, finely coordinated neuro-endocrine regulatory process. Hormonal control through the opposing actions of insulin and glucagon secreted by the islet cells of the pancreas serve as the primary response mechanism to avert post-prandial hyperglycaemia and fasting hypoglycaemia. In addition to this basic response, a range of endocrine mediators concurrently intervene, to enable the fine modulation of the process through a range of insulin-dependent and insulin-independent processes, which ultimately achieve glycaemic control by influencing tissue glucose uptake, glycolysis, glycogenesis, glycogenolysis and gluconeogenesis. More recent evidence supports a central, predominantly hypothalamic role initiated through nutrient (glucose, fatty acid) and hormonal (insulin, leptin, glucagon-like peptide-1) stimuli that influences glucose regulation by direct or indirect effects on skeletal muscle glucose uptake, islet cell insulin/glucagon secretion and hepatic glucose production.
Citation
Nirmalan, N., & Nirmalan, M. (2020). Hormonal control of metabolism : regulation of plasma glucose. Anaesthesia and Intensive Care Medicine, 21(11), 578-583. https://doi.org/10.1016/j.mpaic.2020.08.002
Journal Article Type | Article |
---|---|
Online Publication Date | Sep 21, 2020 |
Publication Date | Nov 1, 2020 |
Deposit Date | Jan 4, 2021 |
Journal | Anaesthesia & Intensive Care Medicine |
Print ISSN | 1472-0299 |
Publisher | Elsevier |
Volume | 21 |
Issue | 11 |
Pages | 578-583 |
DOI | https://doi.org/10.1016/j.mpaic.2020.08.002 |
Publisher URL | https://doi.org/10.1016/j.mpaic.2020.08.002 |
Related Public URLs | https://www.sciencedirect.com/science/journal/14720299 |
You might also like
Selected derivatives of erythromycin B- in silico and anti-malarial studies
(2021)
Journal Article
Downloadable Citations
About USIR
Administrator e-mail: library-research@salford.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search