L Martinez Maestro
Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia
Martinez Maestro, L; Haro-Gonzalez, H; Iglesias-de la Cruz, M C; Sanz-Rodriguez, F; Garcia Sole, J; Jaque, D
Authors
H Haro-Gonzalez
M C Iglesias-de la Cruz
F Sanz-Rodriguez
J Garcia Sole
D Jaque
Abstract
This article demonstrates how controlled hyperthermia at the cellular level can be achieved.The method is based on the simultaneous intracellular incorporation of fluorescence nanothermometers (CdSe quantum dots) and metallic nanoheaters (gold nanorods).Real-time spectral analysis of the quantum dot emission provides a detailed feedback about the intracellular thermal loading caused by gold nanorods excited at the plasmon frequency. Based on this approach, thermal dosimetry is assessed in such a way that the infrared laser (heating) power required to achieve catastrophic intracellular temperature increments in cancer cells is identified.This pure optical method emerges as a new and promising guide for the development of infrared hyperthermia therapies with minimal invasiveness.
Citation
Martinez Maestro, L., Haro-Gonzalez, H., Iglesias-de la Cruz, M. C., Sanz-Rodriguez, F., Garcia Sole, J., & Jaque, D. (2013). Fluorescent nanothermometers provide controlled plasmonic-mediated intracellular hyperthermia. Nanomedicine, 8(3), https://doi.org/10.2217/nnm.12.122
Journal Article Type | Article |
---|---|
Online Publication Date | Mar 11, 2013 |
Publication Date | Mar 11, 2013 |
Deposit Date | Dec 5, 2019 |
Journal | Nanomedicine |
Print ISSN | 1743-5889 |
Electronic ISSN | 1748-6963 |
Publisher | Future Medicine |
Volume | 8 |
Issue | 3 |
DOI | https://doi.org/10.2217/nnm.12.122 |
Publisher URL | https://doi.org/10.2217/nnm.12.122 |
Related Public URLs | https://www.futuremedicine.com/journal/nnm |
Additional Information | Funders : Universidad Autónoma de Madrid;Comunidad Autónoma de Madrid;Spanish Ministerio de Educación y Ciencia;Malta Consolider-Ingenio 2010;FPI grant by Agencia Canaria de Investigación del Gobierno de Canarias;Caja Madrid Foundation |
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