Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs)

Sotgia, F; Fiorillo, M; Lisanti, MP

Abstract

Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, "stemness" and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and ALDH3A1 over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, BCAS1 (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by >100-fold. BCAS1 is a candidate oncogene associated with "stemness" and aggressive oncogenic behavior, such as Tamoxifen resistance.

Citation

Sotgia, F., Fiorillo, M., & Lisanti, M. (2019). Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs). Aging, 11(3), 1065-1068. https://doi.org/10.18632/aging.101822

• Journal Article Type: Article
• Acceptance Date: Feb 7, 2019
• Online Publication Date: Feb 13, 2019
• Publication Date: Feb 13, 2019
• Deposit Date: Mar 1, 2019
• Publicly Available Date: Mar 1, 2019
• Journal: Aging
• Publisher: Impact Journals
• Volume: 11
• Issue: 3
• Pages: 1065-1068
• DOI: https://doi.org/10.18632/aging.101822
• Keywords: anti-oxidant response, cancer cell of origin, cancer stem cells (CSCs), metabolism, senescence, tamoxifen resistance
• Publisher URL: https://doi.org/10.18632/aging.101822
• Related Public URLs: https://www.aging-us.com/