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Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs)

Sotgia, F; Fiorillo, M; Lisanti, MP

Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs) Thumbnail


Authors

M Fiorillo



Abstract

Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, "stemness" and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and ALDH3A1 over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, BCAS1 (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by >100-fold. BCAS1 is a candidate oncogene associated with "stemness" and aggressive oncogenic behavior, such as Tamoxifen resistance.

Citation

Sotgia, F., Fiorillo, M., & Lisanti, M. (2019). Hallmarks of the cancer cell of origin : comparisons with "energetic" cancer stem cells (e-CSCs). Aging, 11(3), 1065-1068. https://doi.org/10.18632/aging.101822

Journal Article Type Article
Acceptance Date Feb 7, 2019
Online Publication Date Feb 13, 2019
Publication Date Feb 13, 2019
Deposit Date Mar 1, 2019
Publicly Available Date Mar 1, 2019
Journal Aging
Publisher Impact Journals
Volume 11
Issue 3
Pages 1065-1068
DOI https://doi.org/10.18632/aging.101822
Keywords anti-oxidant response, cancer cell of origin, cancer stem cells (CSCs), metabolism, senescence, tamoxifen resistance
Publisher URL https://doi.org/10.18632/aging.101822
Related Public URLs https://www.aging-us.com/