A Stewart
Physical cues controlling seasonal immune allocation in a naturally-occurring vertebrate
Stewart, A; Hablützel, PI; Watson, HV; Brown, M; Friberg, IM; Cable, J; Jackson, JA
Authors
PI Hablützel
HV Watson
M Brown
IM Friberg
J Cable
Prof Joseph Jackson J.A.Jackson@salford.ac.uk
Professor
Abstract
Seasonal patterns in immunity are frequently observed in vertebrates but are poorly understood. Here we focussed on a natural piscine model, the three-spined stickleback (Gasterosteus aculeatus), and asked how seasonal immune allocation is driven by physical variables (time, light and heat). Using functionally-relevant gene expression metrics as a reporter of seasonal immune allocation we synchronously sampled fish monthly from the wild (two habitats), and from semi-natural outdoors mesocosms (stocked from one of the wild habitats). This was repeated across two annual cycles, with continuous within-habitat monitoring of environmental temperature and implementing a manipulation of temperature in the mesocosms. We also conducted a long-term laboratory experiment, subjecting acclimated wild fish to natural and accelerated (× 2) photoperiodic change at 7 and 15°C. The laboratory experiment demonstrated that immune allocation was independent of photoperiod and only a very modest effect, at most, was controlled by a tentative endogenous circannual rhythm. On the other hand, experimentally-determined thermal effects were able to quantitatively predict much of the summer-winter fluctuation observed in the field and mesocosms. Importantly, however, temperature was insufficient to fully predict, and occasionally was a poor predictor of, natural patterns. Thermal effects can thus be over-ridden by other (unidentified) natural environmental variation and do not take the form of an unavoidable constraint due to cold-blooded physiology. This is consistent with a context-dependent strategic control of immunity in response to temperature variation, and points to the existence of temperature-sensitive regulatory circuits that might be conserved in other vertebrates.
Citation
Stewart, A., Hablützel, P., Watson, H., Brown, M., Friberg, I., Cable, J., & Jackson, J. (2018). Physical cues controlling seasonal immune allocation in a naturally-occurring vertebrate. Frontiers in Immunology, 9, 582. https://doi.org/10.3389/fimmu.2018.00582
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 8, 2018 |
Online Publication Date | Mar 22, 2018 |
Publication Date | Mar 22, 2018 |
Deposit Date | Mar 8, 2018 |
Publicly Available Date | Mar 27, 2018 |
Journal | Frontiers in Immunology |
Publisher | Frontiers Media |
Volume | 9 |
Pages | 582 |
DOI | https://doi.org/10.3389/fimmu.2018.00582 |
Publisher URL | http://dx.doi.org/10.3389/fimmu.2018.00582 |
Related Public URLs | https://www.frontiersin.org/journals/immunology |
Additional Information | Projects : Thermal variation and immunity in ectothermic vertebrates |
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http://creativecommons.org/licenses/by/4.0/
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Primary research article
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