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Immunotherapy advances for mesothelioma treatment

Bakker, EY; Guazzelli, A; Ashtiani, F; Demonacos, C; Krstic-Demonacos, M; Mutti, L

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Authors

EY Bakker

A Guazzelli

F Ashtiani

C Demonacos

L Mutti



Abstract

Introduction: Mesothelioma is a rare type of cancer that is strongly tied to asbestos exposure. Despite application of different modalities such as chemotherapy, radiotherapy and surgery, patient prognosis remains very poor and therapies are ineffective. Much research currently focuses on the application of novel approaches such as immunotherapy towards this disease.

Areas Covered: The types, stages and aetiology of mesothelioma are detailed, followed by a discussion of the current treatment options such as radiotherapy, surgery, and chemotherapy. A description of innate and adaptive immunity and the principles and justification of immunotherapy is also included. Clinical trials for different immunotherapeutic modalities are described, and lastly the article closes with an expert commentary and five-year view, the former of which is summarised below.

Expert Commentary: Current efforts for novel mesothelioma therapies have been limited by attempting to apply treatments from other cancers, an approach which is not based on a solid understanding of mesothelioma biology. In our view, the influence of the hostile, hypoxic microenvironment and the gene and metabolic changes that resultantly occur should be characterised to improve therapies. Lastly, clinical trials should focus on overall survival rather than surrogate endpoints to avoid bias and inaccurate reflections of treatment effects.

Citation

Bakker, E., Guazzelli, A., Ashtiani, F., Demonacos, C., Krstic-Demonacos, M., & Mutti, L. (2017). Immunotherapy advances for mesothelioma treatment. Expert Review of Anticancer Therapy, 17(9), 799-814. https://doi.org/10.1080/14737140.2017.1358091

Journal Article Type Article
Acceptance Date Jul 18, 2017
Online Publication Date Jul 20, 2017
Publication Date Jul 20, 2017
Deposit Date Jul 25, 2017
Publicly Available Date Jul 20, 2018
Journal Expert Review of Anticancer Therapy
Print ISSN 1473-7140
Electronic ISSN 1744-8328
Publisher Taylor and Francis
Volume 17
Issue 9
Pages 799-814
DOI https://doi.org/10.1080/14737140.2017.1358091
Publisher URL http://dx.doi.org/10.1080/14737140.2017.1358091
Related Public URLs http://www.tandfonline.com/toc/iery20/current

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