microRNAs in cancer

Di Leva, Gianpiero; Garofalo, M; Croce, C

Abstract

MicroRNAs are small non coding RNAs that typically inhibit the translation and stability of
messanger RNAs (mRNAs), controlling genes involved in cellular processes such as
inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and migration.
Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a
cell and their dysregulation has been shown to play an essential role in the development and
progression of cancer. Here, after a brief description of the miRNA genomics, biogenesis and
function, we discuss the effects of miRNA deregulation in the cellular pathways that lead to the
progressive conversion of normal cells into cancer cells and the potential to develop new
molecular miRNA-targeted therapies.

Citation

Di Leva, G., Garofalo, M., & Croce, C. (2014). microRNAs in cancer. https://doi.org/10.1146/annurev-pathol-012513-104715

• Journal Article Type: Article
• Online Publication Date: Sep 25, 2013
• Publication Date: Jan 1, 2014
• Deposit Date: Jul 26, 2016
• Journal: Annual Review Pathology
• Volume: 9
• Pages: 287-314
• DOI: https://doi.org/10.1146/annurev-pathol-012513-104715.
• Publisher URL: http://dx.doi.org/10.1146/annurev-pathol-012513-104715
• Related Public URLs: http://www.annualreviews.org/journal/pathmechdis
• Additional Information: Funders : NIH;Kimmel Cancer Foundation