Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth

Martinez-Outschoorn, UE; Sotgia, F; Lisanti, MP

Abstract

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.

Citation

Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

• Journal Article Type: Article
• Online Publication Date: Jul 14, 2014
• Publication Date: Jul 14, 2014
• Deposit Date: Jul 5, 2016
• Journal: Cancer Cell
• Print ISSN: 1535-6108
• Publisher: Elsevier
• Volume: 26
• Issue: 1
• Pages: 5-7
• DOI: https://doi.org/10.1016/j.ccr.2014.06.021
• Publisher URL: http://dx.doi.org/10.1016/j.ccr.2014.06.021
• Related Public URLs: http://www.sciencedirect.com/science/journal/15356108
• Additional Information: Funders : Funder not known