Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose

Peiris-Pagès, M; Sotgia, Federica; Lisanti, MP

Abstract

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or tumour-initiating cells (TICs) [1]. Recent publications identify several antibiotics, such as salinomycin or doxycycline, as selective CSCs inhibitors [2-4]. However, the mechanisms of action of these antibiotics on CSCs are not fully understood.

Citation

Peiris-Pagès, M., Sotgia, F., & Lisanti, M. (2015). Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose. Oncoscience, 2(8), 696-699. https://doi.org/10.18632/oncoscience.215

• Journal Article Type: Article
• Acceptance Date: Aug 16, 2015
• Online Publication Date: Aug 24, 2015
• Publication Date: Aug 24, 2015
• Deposit Date: Jun 29, 2016
• Publicly Available Date: Jun 29, 2016
• Journal: Oncoscience
• Electronic ISSN: 2331-4737
• Publisher: Impact Journals
• Volume: 2
• Issue: 8
• Pages: 696-699
• DOI: https://doi.org/10.18632/oncoscience.215
• Publisher URL: http://dx.doi.org/10.18632/oncoscience.215
• Related Public URLs: http://www.impactjournals.com/oncoscience/