Cancer stem cell metabolism

Peiris-Pagès, M; Martinez-Outschoorn, U; Pestell, R; Sotgia, F; Lisanti, MP

Abstract

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.

Citation

Peiris-Pagès, M., Martinez-Outschoorn, U., Pestell, R., Sotgia, F., & Lisanti, M. (2016). Cancer stem cell metabolism. Breast Cancer Research, 18(55), https://doi.org/10.1186/s13058-016-0712-6

• Journal Article Type: Article
• Acceptance Date: Apr 25, 2016
• Online Publication Date: May 24, 2016
• Publication Date: May 24, 2016
• Deposit Date: Jun 29, 2016
• Publicly Available Date: Jun 29, 2016
• Journal: Breast Cancer Research
• Print ISSN: 1465-5411
• Publisher: Springer Verlag
• Volume: 18
• Issue: 55
• DOI: https://doi.org/10.1186/s13058-016-0712-6
• Publisher URL: http://dx.doi.org/10.1186/s13058-016-0712-6
• Related Public URLs: http://breast-cancer-research.biomedcentral.com/
• Additional Information: Funders : Funder not known