A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice

Goodhead, IB; Archibald, A; Amwayi, P; Brass, A; Gibson, J; Hall, N; Hughes, M; Limo, M; Iraqi, F; Kemp, SJ

Abstract

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two independent crosses between susceptible A/J and BALB/c mice, and the resistant C57BL/6. These were designated Tir1, Tir2 and Tir3 for Trypanosoma infection response, and range in size from 0.9–12 cM.

• Journal Article Type: Article
• Acceptance Date: Oct 12, 2010
• Publication Date: Nov 9, 2010
• Deposit Date: Sep 23, 2015
• Publicly Available Date: Apr 5, 2016
• Journal: PLoS Neglected Tropical Diseases
• Electronic ISSN: 1935-2735
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 11
• Pages: e880-e880
• DOI: https://doi.org/10.1371/journal.pntd.0000880
• Publisher URL: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0000880
• Related Public URLs: http://journals.plos.org/plosntds/
• Additional Information: Additional Information : Unmapped bibliographic data: Y1 - 2010/// [EPrints field already has value set]; Grant Number: GR066764MA