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A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice

Goodhead, IB; Archibald, A; Amwayi, P; Brass, A; Gibson, J; Hall, N; Hughes, M; Limo, M; Iraqi, F; Kemp, SJ

A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice Thumbnail


Authors

A Archibald

P Amwayi

A Brass

J Gibson

N Hall

M Hughes

M Limo

F Iraqi

SJ Kemp



Abstract

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in two independent crosses between susceptible A/J and BALB/c mice, and the resistant C57BL/6. These were designated Tir1, Tir2 and Tir3 for Trypanosoma infection response, and range in size from 0.9–12 cM.

Citation

Goodhead, I., Archibald, A., Amwayi, P., Brass, A., Gibson, J., Hall, N., …Kemp, S. (2010). A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Neglected Tropical Diseases, 4(11), e880-e880. https://doi.org/10.1371/journal.pntd.0000880

Journal Article Type Article
Acceptance Date Oct 12, 2010
Publication Date Nov 9, 2010
Deposit Date Sep 23, 2015
Publicly Available Date Apr 5, 2016
Journal PLoS Neglected Tropical Diseases
Electronic ISSN 1935-2735
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 4
Issue 11
Pages e880-e880
DOI https://doi.org/10.1371/journal.pntd.0000880
Publisher URL http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0000880
Related Public URLs http://journals.plos.org/plosntds/
Additional Information Additional Information : Unmapped bibliographic data: Y1 - 2010/// [EPrints field already has value set]
Grant Number: GR066764MA

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