M Picardeau
Multi-Locus sequence analysis reveals profound enetic diversity among isolates of the human athogen bartonella bacilliformis
Picardeau, M; Chaloner, GL; Palmira Ventosilla; Birtles, RJ
Abstract
Bartonella bacilliformis is the aetiological agent of human bartonellosis, a potentially life threatening infection of significant
public health concern in the Andean region of South America. Human bartonellosis has long been recognised in the region
but a recent upsurge in the number of cases of the disease and an apparent expansion of its geographical distribution have
re-emphasized its contemporary medical importance. Here, we describe the development of a multi-locus sequence typing
(MLST) scheme for B. bacilliformis and its application to an archive of 43 isolates collected from patients across Peru. MLST
identified eight sequence types among these isolates and the delineation of these was generally congruent with those of
the previously described typing scheme. Phylogenetic analysis based on concatenated sequence data derived from MLST
loci revealed that seven of the eight sequence types were closely related to one another; however, one sequence type, ST8,
exhibited profound evolutionary divergence from the others. The extent of this divergence was akin to that observed
between other members of the Bartonella genus, suggesting that ST8 strains may be better considered as members of a
novel Bartonella genospecies.
Citation
Picardeau, M., Chaloner, G., Palmira Ventosilla, & Birtles, R. (2011). Multi-Locus sequence analysis reveals profound enetic diversity among isolates of the human athogen bartonella bacilliformis. PLoS Neglected Tropical Diseases, 5(7), e1248. https://doi.org/10.1371/journal.pntd.0001248
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2011 |
Deposit Date | Nov 6, 2014 |
Publicly Available Date | Apr 5, 2016 |
Journal | PLoS Neglected Tropical Diseases |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 7 |
Pages | e1248 |
DOI | https://doi.org/10.1371/journal.pntd.0001248 |
Publisher URL | http://dx.doi.org/10.1371/journal.pntd.0001248 |
Related Public URLs | http://journals.plos.org/plosntds/ |
Additional Information | Funders : Biotechnology and Biosciences Sciences Research Council (BBSRC) |
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http://creativecommons.org/licenses/by/3.0/
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