Novel therapeutic strategies to counter pseudomonas aeruginosa infections

Fothergill, J; Winstanley, C; James, C

Abstract

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic
multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms.
During chronic infection, the bacterium can form a protective biofilm therefore reducing the
efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence
factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics
are under investigation such as those directed against biofilm formation and quorum-sensing
systems along with bacteriophages and immunotherapies. Recent advances in next-generation
sequencing and comparative genomics have opened the door to a new wave of smart drug
design that could revolutionize P. aeruginosa treatment options.

Citation

Fothergill, J., Winstanley, C., & James, C. Novel therapeutic strategies to counter pseudomonas aeruginosa infections. Expert Review of Anti-infective Therapy, 10(2), 219-235. https://doi.org/10.1586/eri.11.168

• Journal Article Type: Article
• Deposit Date: Mar 21, 2013
• Journal: Expert Reviews of Anti Infective Therapy
• Print ISSN: 1478-7210
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 2
• Pages: 219-235
• DOI: https://doi.org/10.1586/eri.11.168
• Publisher URL: http://dx.doi.org/10.1586/eri.11.168
• Related Public URLs: http://www.expert-reviews.com/loi/eri