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A first step towards learning which uORFs regulate gene expression

, Selpi; Bryant, CH; Kemp, GJL; Cvijovic, M

Authors

Selpi

GJL Kemp

M Cvijovic



Abstract

We have taken a first step towards learning which upstream Open Reading Frames (uORFs) regulate gene expression (i.e., which uORFs are functional) in the yeast Saccharomyces cerevisiae. We do this by integrating data from several resources and combining a bioinformatics tool, ORF Finder, with a machine learning technique, Inductive Logic Programming (ILP). Here, we report the challenge of using ILP as part of this integrative system, in order to automatically generate a model that identifies functional uORFs. Our method makes searching for novel functional uORFs more efficient than random sampling. An attempt has been made to predict novel functional uORFs using our method. Some preliminary evidence that our model may be biologically meaningful is presented.

Citation

Bryant, C., Kemp, G., & Cvijovic, M. (2006). A first step towards learning which uORFs regulate gene expression. Journal of Integrative Bioinformatics, 3(2), 31. https://doi.org/10.2390/biecoll-jib-2006-31

Journal Article Type Article
Publication Date Aug 1, 2006
Deposit Date Feb 16, 2009
Publicly Available Date Feb 16, 2009
Journal Journal of Integrative Bioinformatics
Publisher De Gruyter
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
Pages 31
DOI https://doi.org/10.2390/biecoll-jib-2006-31
Publisher URL http://dx.doi.org/10.2390/biecoll-jib-2006-31
Additional Information Paper presented at the 3rd International Workshop on Integrative Bioinformatics, 2006

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