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Unique family clustering of human echinococcosis cases in a Chinese community

Yang, YR; Ellis, M; Sun, T; Li, Z; Liu, X; Vuitton, DA; Bartholomot, B; Giraudoux, P; Craig, PS; Boufana, B; Wang, Y; Feng, X; Wen, H; Ito, A; McManus, DP

Authors

YR Yang

M Ellis

T Sun

Z Li

X Liu

DA Vuitton

B Bartholomot

P Giraudoux

PS Craig

B Boufana

Y Wang

X Feng

H Wen

A Ito

DP McManus



Abstract

We have identified a significant focus and unusual clustering of human cases of cystic echinococcosis (CE) and alveolar echinococcosis (AE) in the village of Nanwan, Xiji County, Ningxia Hui Autonomous Region, in one of the most highly endemic areas for both diseases in China. The village, a Chinese Hui Islamic community, is composed of 167 members of four extended families. A total of 28 people died (12 of echinococcosis) since the village was first settled in the 1950s. Despite similar life patterns, the number of AE and CE cases occurring in each family was different. Overall, the prevalences of AE and CE were 9% (20 cases) and 5.9% (13 cases), with a combined prevalence of 14.9%. In contrast to CE, a comparison of the prevalence of AE indicated significant differences between the four family clusters. Although suggestive that host genotype might play a role in susceptibility to AE, this hypothesis requires further investigation.

Citation

Yang, Y., Ellis, M., Sun, T., Li, Z., Liu, X., Vuitton, D., …McManus, D. (2006). Unique family clustering of human echinococcosis cases in a Chinese community. American Journal of Tropical Medicine and Hygiene, 74(3), 487-494. https://doi.org/10.4269/ajtmh.2006.74.487

Journal Article Type Article
Publication Date Mar 1, 2006
Deposit Date Aug 8, 2007
Journal The American Journal of Tropical Medicine and Hygiene
Print ISSN 0002-9637
Publisher American Society of Tropical Medicine and Hygiene
Peer Reviewed Peer Reviewed
Volume 74
Issue 3
Pages 487-494
DOI https://doi.org/10.4269/ajtmh.2006.74.487
Publisher URL http://dx.doi.org/10.4269/ajtmh.2006.74.487
Related Public URLs http://www.ajtmh.org/