Simultaneous determination of 4-aminophenol and paracetamol based on CS-Ni nanocomposite-modified screen-printed disposable electrodes

Abdi, S; Chelaghmia, ML; Kihal, R; Banks, C.E; Ferrari, A; Fisli, H; Nacef, M; Affoune, AM; Benhamza, MEH

Abstract

In the present work, chitosan-coated nickel nanoparticles (CS-Ni) were successfully prepared onto screen-printed electrode (SPE) by electrodeposition method with the assistance of an anionic surfactant of sodium dodecyl sulfate (SDS) for the individual and simultaneous sensing of 4-aminophenol (4-AP) and paracetamol (PA). The as-prepared sensor was characterized via scanning electron microscopy, X-ray diffraction, and fourier transform infrared techniques. The electrochemical catalytic behaviors of the 4-AP and PA on the fabricated NiNPs-SDS/CS/SPE electrode were explored using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The NiNPS-SDS/CS modified screen-printed electrode demonstrated excellent electrocatalytic activity for 4-AP and PA, indicating that nickel microstructures have a high specific surface area, excellent electrical conductivity, and high electrocatalytic activity. The results indicate that CV and DPV could be easily applied to determine 4-AP and PA using the fabricated sensor under optimized conditions. However, CV is preferred for both analysts’ sensing, with the largest linear range from 1 to 500 μM for 4-AP (R2 = 0.999) and 1 μM to 2 mM (R2 = 0.997) for PA, respectively. In terms of sensitivity and detection limit, DPVs response appeared to be a better technique choice, as it revealed the highest sensitivity values of 0.959 µA µM−1 cm−2 for 4-AP and 1.163 µA µM−1 cm−2 for PA, with the lowest detection limits of 0.06 and 0.04 μM for 4-AP and PA (S/N = 3), respectively. With a high recovery rate, good selectivity, excellent reproducibility, and strong anti-interference ability, the modified sensor was successfully applied to the simultaneous detection of 4-AP and PA in pharmaceutical tablets. It is expected to be widely used in actual sample detection.

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2023
• Publication Date: Apr 13, 2023
• Deposit Date: Jun 12, 2023
• Journal: Monatshefte für Chemie - Chemical Monthly
• Print ISSN: 0026-9247
• Electronic ISSN: 1434-4475
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 154
• Pages: 563-575
• DOI: https://doi.org/10.1007/s00706-023-03062-7