Wedge resection versus lobectomy in T1 lung cancer patients: a propensity matched analysis

Moon, Robert J; Taylor, Rebecca; Miklavc, Pika; Mehdi, Syed B; Grant, Stuart W; Bittar, Mohamad Nidal

Abstract

Objectives: Performing wedge resection rather than lobectomy for primary lung cancer remains controversial. Recent studies demonstrate no survival advantage for non-anatomical resection compared to lobectomy in patients with early-stage lung cancer. The objective of this study was to investigate whether in patients with T1 tumours, non-anatomical wedge resection is associated with equivalent survival to lobectomy. Methods: This was a retrospective cohort study of patients who underwent lung resection at the Lancashire Cardiac Centre between April 2005 and April 2018. Patients were subjected to multidisciplinary team discussion. The extent of resection was decided by the team based on British Thoracic Society guidelines. The primary outcome was overall survival. Propensity matching of patients with T1 tumours was also performed to determine whether differences in survival rates exist in a subset of these patients with balanced pre-operative characteristics. Results: There were 187 patients who underwent non-anatomical wedge resection and 431 patients who underwent lobectomy. Cox modelling demonstrated no survival difference between groups for the first 1.6 years then a risk of death 3-fold higher for wedge resection group after 1.6 years (HR 3.14, CI 1.98–4.79). Propensity matching yielded 152 pairs for which 5-year survival was 66.2% for the lobectomy group and 38.5% for the non-anatomical wedge group (SMD = 0.58, p = 0.003). Conclusions: Non-anatomical wedge resection was associated with significantly reduced 5-year survival compared to lobectomy in matched patients. Lobectomy should remain the standard of care for patients with early-stage lung cancer who are fit enough to undergo surgical resection.

Citation

Moon, R. J., Taylor, R., Miklavc, P., Mehdi, S. B., Grant, S. W., & Bittar, M. N. (in press). Wedge resection versus lobectomy in T1 lung cancer patients: a propensity matched analysis. Journal of Cardiothoracic Surgery, 18(1), 252. https://doi.org/10.1186/s13019-023-02303-4

• Journal Article Type: Article
• Acceptance Date: Jun 10, 2023
• Online Publication Date: Aug 24, 2023
• Deposit Date: Aug 31, 2023
• Publicly Available Date: Aug 31, 2023
• Journal: Journal of Cardiothoracic Surgery
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 1
• Pages: 252
• DOI: https://doi.org/10.1186/s13019-023-02303-4
• Keywords: Wedge, Lobectomy, Lung, Cancer, Survival, Resection