Integrating gene selection and deep learning for enhanced Autisms' disease prediction: a comparative study using microarray data

Abdelwahab, Mahmoud M.; Al-Karawi, Khamis A.; Semary, H. E.

Abstract

<abstract> <p>In this article, Autism Spectrum Disorder (ASD) is discussed, with an emphasis placed on the multidimensional nature of the disorder, which is anchored in genetic and neurological components. Identifying genes related to ASD is essential to comprehend the mechanisms that underlie the illness, yet the condition's complexity has impeded precise information in this field. In ASD research, the analysis of gene expression data helps choose and categorize significant genes. The study used microarray data to provide a novel approach that integrated gene selection techniques with deep learning models to improve the accuracy of ASD prediction. It offered a detailed comparative examination of gene selection approaches and deep learning architectures, including singular value decompositions (SVD), principal component analyses (PCA), and convolutional neural networks (CNNs). This paper combines gene selection methods (PCA and SVD) with deep learning models (CNN) to improve ASD prediction. Compared to more traditional approaches, the study revealed that its integrated methodology was more effective in improving the accuracy of ASD prediction results through experimentation. There was a difference in the accuracy between the PCA-CNN model, which achieved 94.33% with a loss of 0.4312, and the SVD-CNN model, which achieved 92.21% with a loss less than or equal to 0.3354. These discoveries help in the development of more accurate diagnostic and prognostic tools for ASD, which is a complicated neurodevelopmental disorder. Additionally, they provide insights into the molecular pathways that underlie ASD.</p> </abstract>

Citation

Abdelwahab, M. M., Al-Karawi, K. A., & Semary, H. E. (2024). Integrating gene selection and deep learning for enhanced Autisms' disease prediction: a comparative study using microarray data. AIMS journal, 9(7), 17827-17846. https://doi.org/10.3934/math.2024867

• Journal Article Type: Article
• Acceptance Date: May 20, 2024
• Publication Date: Jun 7, 2024
• Deposit Date: Jun 12, 2024
• Publicly Available Date: Jun 12, 2024
• Journal: AIMS Mathematics
• Print ISSN: 1357-9657
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 7
• Pages: 17827-17846
• DOI: https://doi.org/10.3934/math.2024867