Development of a novel and versatile synthesis for a potentially therapeutic di-aryl-alkylamine and related analogues

Murphy, Christopher

Abstract

Fendiline is an obsolete ion channel inhibitor originally prescribed as an anti-hypertensive medicine. However, recent repurposing has shown promising efficacy towards a range of serious ailments, most notably carcinomas including pancreatic and colon, as well as parasites such as malaria. Research has revealed several valuable bioactivities including inhibition of oncogenic signalling pathways, tumour suppression, as well as effectiveness as a potentiator in combination therapy along with contemporary anticancer and anti-malarial medicines.
The aim of the research conducted in this thesis looked to trial two novel synthetic procedures targeted at generating R-fendiline, along with a range of substituted derivatives. Despite unexpected complications arising from the second and third steps, the primary four-step procedure was successfully carried out to completion. Herein two analogues of the target molecule, one of them completely novel to the current synthetic literature, were generated and spectroscopically characterised. A shorter two-step synthesis attempted, however, was deemed unsuccessful despite modification.

• Thesis Type: Thesis
• Deposit Date: Jul 2, 2024
• Publicly Available Date: Oct 27, 2024
• Award Date: Sep 26, 2024