Modelling the molecular mechanisms of aging

Mc Auley, Mark T.; Guimera, Alvaro Martinez; Hodgson, David; Mcdonald, Neil; Mooney, Kathleen M.; Morgan, Amy E.; Proctor, Carole J.

Abstract

The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process. The complexity of the aging process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards and discusses many specific examples of models that have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.

Citation

Mc Auley, M., Guimera, A., Hodgson, D., Mcdonald, N., Mooney, K., Morgan, A., & Proctor, C. (2017). Modelling the molecular mechanisms of aging. Bioscience Reports, 37(1), https://doi.org/10.1042/BSR20160177

• Journal Article Type: Article
• Online Publication Date: Feb 23, 2017
• Publication Date: Feb 28, 2017
• Deposit Date: Aug 22, 2024
• Publicly Available Date: Sep 19, 2024
• Journal: Bioscience Reports
• Print ISSN: 0144-8463
• Electronic ISSN: 1573-4935
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 37
• Issue: 1
• DOI: https://doi.org/10.1042/BSR20160177