Systems-Based Mechanisms of Aging

Proctor, Carole J; Morgan, Amy E; Mc Auley, Mark T

Abstract

The last number of decades have witnessed an unrelenting global rise in the number of older people. This demographic shift is laudable; however, many older people are burdened by poor health. The main reason so many older people have their healthspan compromised is due to the complex biology which underpins aging and the diseases which are associated with this intriguing phenomenon. Fortunately, however, in recent years there has been a paradigm shift within biological research which has seen the emergence of systems biology. In contrast to a reductionist approach which was commonplace in biological research for many years, systems biology seeks to understand biological systems in an integrated manner. Investigating aging and age related disease in this way is becoming increasingly effective. In this article we discuss the methods which underpin systems approaches and provide examples of their application to biogerontology research.

Citation

Proctor, C. J., Morgan, A. E., & Mc Auley, M. T. (2019). Systems-Based Mechanisms of Aging. In Encyclopedia of Biomedical Gerontology (332-345). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.11424-2

• Online Publication Date: Nov 29, 2019
• Publication Date: Nov 29, 2019
• Deposit Date: Aug 22, 2024
• Publisher: Elsevier
• Pages: 332-345
• Series Title: Reference Module in Biomedical Sciences
• Book Title: Encyclopedia of Biomedical Gerontology
• ISBN: 9780128012383
• DOI: https://doi.org/10.1016/B978-0-12-801238-3.11424-2