Dr Willian Da Silveira W.A.DaSilveira@salford.ac.uk
Lecturer
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
Abraham da Silveira, Willian; Fazelinia, Hossein; Rosenthal, Sara; Laiakis, Evagelia C.; Kim, Man S.; Meydan, Cem; Kidane, Yared; Rathi, Komal S.; Smith, Scott M.; Stear, Benjamin; Ying, Yue; Zhang, Yuanchao; Foox, Jonathan; Zanello, Susana; Crucian, Brian; Wang, Dong; Nugent, Adrienne; Costa, Helio A.; Zwart, Sara R.; Schrepfer, Sonja; Elworth, R.A. Leo; Sapoval, Nicolae; Treangen, Todd; MacKay, Matthew; Gokhale, Nandan S.; Horner, Stacy M.; Singh, Larry N.; Wallace, Douglas C.; Willey, Jeffrey S.; Schisler, Jonathan C.; Meller, Robert; McDonald, J. Tyson; Fisch, Kathleen M.; Hardiman, Gary; Taylor, Deanne; Mason, Christopher E.; Costes, Sylvain V.; Beheshti, Afshin
Authors
Hossein Fazelinia
Sara Rosenthal
Evagelia C. Laiakis
Man S. Kim
Cem Meydan
Yared Kidane
Komal S. Rathi
Scott M. Smith
Benjamin Stear
Yue Ying
Yuanchao Zhang
Jonathan Foox
Susana Zanello
Brian Crucian
Dong Wang
Adrienne Nugent
Helio A. Costa
Sara R. Zwart
Sonja Schrepfer
R.A. Leo Elworth
Nicolae Sapoval
Todd Treangen
Matthew MacKay
Nandan S. Gokhale
Stacy M. Horner
Larry N. Singh
Douglas C. Wallace
Jeffrey S. Willey
Jonathan C. Schisler
Robert Meller
J. Tyson McDonald
Kathleen M. Fisch
Gary Hardiman
Deanne Taylor
Christopher E. Mason
Sylvain V. Costes
Afshin Beheshti
Abstract
Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA's GeneLab derived from hundreds of samples flown in space to determine transcriptomic, proteomic, metabolomic, and epigenetic responses to spaceflight. Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions. Importantly, NASA's Twin Study provided a platform to confirm several of our principal findings. Evidence of altered mitochondrial function and DNA damage was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, indicating mitochondrial stress as a consistent phenotype of spaceflight.
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Nov 2, 2020 |
| Publication Date | Nov 25, 2020 |
| Deposit Date | Oct 25, 2024 |
| Journal | Cell |
| Print ISSN | 0092-8674 |
| Electronic ISSN | 1097-4172 |
| Publisher | Elsevier |
| Peer Reviewed | Peer Reviewed |
| Volume | 183 |
| Issue | 5 |
| Pages | 1185-1201.e20 |
| DOI | https://doi.org/10.1016/j.cell.2020.11.002 |
| PMID | 33242417 |