A systems biology approach reveals the endocrine disrupting potential of Aflatoxin B1

U. Verga, Jacopo; Padovano, Costanzo; Abraham da Silveira, Willian; Starr Hazard, E.; Nugent, Anne P.; T. Elliott, Christopher; Carnevali, Oliana; Galeazzi, Roberta; Hardiman, Gary

Abstract

Aflatoxin B1 (AFB1) a mycotoxin produced by Aspergillus flavus and A. parasiticus is a potent carcinogen and causative agent of hepatocellular carcinoma (HCC). It is a food contaminant which presents a major risk to human health. AFB1 contamination poses a significant economic burden, as 25% of the world's food crops need to be destroyed annually. The mechanism of action (MOA) of aflatoxins remains to be fully elucidated. Recent findings suggest that AFB1 mediated endocrine disruption may occur in the population of regions with high contamination, even without evidence of direct dietary intake.

• Journal Article Type: Article
• Acceptance Date: May 1, 2023
• Online Publication Date: May 13, 2023
• Publication Date: May 13, 2023
• Deposit Date: Oct 25, 2024
• Publicly Available Date: Oct 28, 2024
• Journal: Exposure and Health
• Print ISSN: 2451-9766
• Electronic ISSN: 2451-9685
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 2
• Pages: 321-340
• DOI: https://doi.org/10.1007/s12403-023-00557-w
• Additional Information: Received: 25 August 2022; Revised: 16 February 2023; Accepted: 17 April 2023; First Online: 13 May 2023; : ; : G.H. is a founder of Altomics Datamation Ltd. and a member of its scientific advisory board.