'The Role of Extracellular microRNA in the Treatment of Medulloblastoma' by Oyindamola Amusan

Amusan, Oyindamola

Abstract

SPARC 2021 Poster No. 21

Medulloblastoma (MB) is one of the most common, aggressive forms of childhood brain cancer. It has a poor detection in its early stage which affects treatment. Currently, the treatment for MB includes surgery, radiation, and drugs to kill the cancer cells, which results in severe and long-term side effects. However, research has shown that cancerous cells releases a large amount of membrane bound extracellular vesicles, otherwise called (EVs). EVs plays an important role in cell-to-cell communication and serve as carriers for biological materials such as DNA, RNA, and microRNAs. EVs are known to be disease marker in human diseases including cancer, microRNAs are discovered to be loaded in the EVs. Hence, microRNA carried by EVs may highlight a new mechanism in cancer progression, which leads to the identification of disease markers that can be used in the long run for the treatment of MB. This research explores the role of microRNA carried by EVs in improving the treatment of MB. We have studied the effect of an approved drug compound (Cisplatin) used as a standard treatment on MB, on a brain cell (MB03) to examine the presence of selected extracellular microRNA released from brain cell line. After treatment with Cisplatin, we checked the altered expression of selected microRNAs released from brain cell line, to evaluate the functional role of the selected microRNAs. To this end, the focus of this research is to identify extracellular microRNAs as a possible disease marker, for early detection and hence, improving the treatment of MB.

• Online Publication Date: Jun 21, 2021
• Publication Date: Jun 22, 2021
• Deposit Date: Feb 6, 2025
• DOI: https://doi.org/10.17866/rd.salford.14815590.v1
• Publisher URL: https://salford.figshare.com/articles/poster/_The_Role_of_Extracellular_microRNA_in_the_Treatment_of_Medulloblastoma_by_Oyindamola_Amusan/14815590
• Collection Date: Jun 21, 2021