All Outputs (2)

Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease (2020)
Journal Article
Morgan, A. E., Acutt, K. D., & Mc Auley, M. (2020). Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease. Bioscience Reports, 40(11), https://doi.org/10.1042/BSR20202571

There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is associated with the hypermethylation of many gene promoters, among which are developmental g... Read More about Electrochemically detecting DNA methylation in the EN1 gene promoter: Implications for understanding ageing and disease.

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms (2020)
Journal Article
Morgan, A. E., & Mc Auley, M. T. (2020). Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. Biology, 9(10), Article 314. https://doi.org/10.3390/biology9100314

The dysregulation of intracellular cholesterol homeostasis is associated with several age-related diseases, most notably cardiovascular disease (CVD). Research in this area has benefitted from using computational modelling to study the inherent compl... Read More about Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.