All Outputs (3)

Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2 (2010)
Journal Article
Sayan, B., Yang, A., Conforti, F., Tucci, P., Piro, M., Browne, G., …Melino, G. (2010). Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proceedings of the National Academy of Sciences, 107(29), https://doi.org/10.1073/pnas.0911828107

p73 is a p53-related transcription factor with fundamental roles in development and tumor suppression. Transcription from two different promoters on the p73 gene results in generation of transcriptionally active TAp73 isoforms and dominant negative D... Read More about Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2.

p73 and p63 regulate the expression of fibroblast growth factor receptor 3 (2010)
Journal Article
Sayan, A., D'Angelo, B., Sayan, B., Tucci, P., Cimini, A., Ceru, M., …Melino, G. (2010). p73 and p63 regulate the expression of fibroblast growth factor receptor 3. Biochemical and Biophysical Research Communications, 394(3), 824-828. https://doi.org/10.1016/j.bbrc.2010.03.084

p53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (ΔN) isoforms and their mRNAs are subjec... Read More about p73 and p63 regulate the expression of fibroblast growth factor receptor 3.

The microRNA and p53 families join forces against cancer (2010)
Journal Article
Barlev, N., Sayan, B., Candi, E., & Okorokov, A. (2010). The microRNA and p53 families join forces against cancer. Cell Death and Differentiation, 17, 373-375. https://doi.org/10.1038/cdd.2009.73

The product of the TP53 gene, p53, is one of the most recognised and extensively studied molecules that protects multicellular organisms from cancer. The well-deserved fame of p53 stems from the nature of its function – to coordinate an appropriate c... Read More about The microRNA and p53 families join forces against cancer.