All Outputs (5)

Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma (2021)
Journal Article
Lawson, C., Ahmed Alta, T., Moschou, G., Skamnaki, V., Solovou, T., Topham, C., …Snape, T. (2021). Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma. European Journal of Medicinal Chemistry, 225, 113751. https://doi.org/10.1016/j.ejmech.2021.113751

Medulloblastoma - highly aggressive and heterogeneous tumours of the cerebellum - account for 15-20% of all childhood brain tumours, and are the most common high-grade childhood embryonal tumour of the central nervous system. Herein, potent in vitro... Read More about Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers (2016)
Journal Article
Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A., & Taylor, S. (2016). Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology, 6(8), https://doi.org/10.1098/rsob.160134

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy a... Read More about Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.

Mcl-1 dynamics influence mitotic slippage and death in mitosis (2016)
Journal Article
Sloss, O., Topham, C., Diez, M., & Taylor, S. (2016). Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget, 7, 5176-5192. https://doi.org/10.18632/oncotarget.6894

Microtubule-binding drugs such as taxol are frontline treatments for a variety of cancers but exactly how they yield patient benefit is unclear. In cell culture, inhibiting microtubule dynamics prevents spindle assembly, leading to mitotic arrest fol... Read More about Mcl-1 dynamics influence mitotic slippage and death in mitosis.

MYC is a major determinant of mitotic cell fate (2015)
Journal Article
Topham, C., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., …Taylor, S. (2015). MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), 129-140. https://doi.org/10.1016/j.ccell.2015.06.001

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer.... Read More about MYC is a major determinant of mitotic cell fate.