All Outputs (9)

The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma (2024)
Thesis
Amusan, O. (2024). The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma. (Thesis). University of Salford

Small extracellular vesicles (sEVs) cargo can potentially alter response to chemotherapy, indicating specific cargo as a potential theranostic biomarker. In this study, we explored miRNAs mediated sEVs for chemotherapy associated biomarkers. We took... Read More about The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma.

Targeting c-met in sonic hedgehog medulloblastomas (2022)
Thesis
Morlando, S. Targeting c-met in sonic hedgehog medulloblastomas. (Thesis). University of Salford

Medulloblastoma (MB), a cerebellar tumour primarily diagnosed in children, is the most common malignant brain tumour consisting of four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients... Read More about Targeting c-met in sonic hedgehog medulloblastomas.

Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma (2021)
Journal Article
Lawson, C., Ahmed Alta, T., Moschou, G., Skamnaki, V., Solovou, T., Topham, C., …Snape, T. (2021). Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma. European Journal of Medicinal Chemistry, 225, 113751. https://doi.org/10.1016/j.ejmech.2021.113751

Medulloblastoma - highly aggressive and heterogeneous tumours of the cerebellum - account for 15-20% of all childhood brain tumours, and are the most common high-grade childhood embryonal tumour of the central nervous system. Herein, potent in vitro... Read More about Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma.

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Mechanisms of medulloblastoma vulnerability and new targeted therapies (2020)
Thesis
Buzzetti, M. Mechanisms of medulloblastoma vulnerability and new targeted therapies. (Thesis). University of Salford

Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activa... Read More about Mechanisms of medulloblastoma vulnerability and new targeted therapies.

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers (2016)
Journal Article
Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A., & Taylor, S. (2016). Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology, 6(8), https://doi.org/10.1098/rsob.160134

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy a... Read More about Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.

Mcl-1 dynamics influence mitotic slippage and death in mitosis (2016)
Journal Article
Sloss, O., Topham, C., Diez, M., & Taylor, S. (2016). Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget, 7, 5176-5192. https://doi.org/10.18632/oncotarget.6894

Microtubule-binding drugs such as taxol are frontline treatments for a variety of cancers but exactly how they yield patient benefit is unclear. In cell culture, inhibiting microtubule dynamics prevents spindle assembly, leading to mitotic arrest fol... Read More about Mcl-1 dynamics influence mitotic slippage and death in mitosis.

MYC is a major determinant of mitotic cell fate (2015)
Journal Article
Topham, C., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., …Taylor, S. (2015). MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), 129-140. https://doi.org/10.1016/j.ccell.2015.06.001

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer.... Read More about MYC is a major determinant of mitotic cell fate.