Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia

Guo, H-M; Gao, J-M; Luo, Y-L; Wen, Y-Z; Zhang, Y-L; Hide, G; Zhou, W-L; Ayala, FJ; Lun, Z-R

doi:10.1073/pnas.1503474112

All Outputs (5)

Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen (2015)
Journal Article
Lin, R., Lai, D., Zheng, L., Wu, J., Lukeš, J., Hide, G., & Lun, Z. (2015). Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites and Vectors, 8(1), 665. https://doi.org/10.1186/s13071-015-1281-8

BACKGROUND

The haemoflagellate Trypanosoma lewisi is a kinetoplastid parasite which, as it has been recently reported to cause human disease, deserves increased attention. Characteristic features of all kinetoplastid flagellates are a uniquely st... Read More about Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen.

High prevalence of trypanosomes in European badgers detected using ITS-PCR (2015)
Journal Article
Ideozu, E., Whiteoak, A., Tomlinson, A., Robertson, A., Delahay, R., & Hide, G. (2015). High prevalence of trypanosomes in European badgers detected using ITS-PCR. Parasites and Vectors, 8(480), https://doi.org/10.1186/s13071-015-1088-7

Background
Wildlife can be important sources and reservoirs for pathogens. Trypanosome infections are common in many mammalian species, and are pathogenic in some. Molecular detection tools were used to measure trypanosome prevalence in a well-stud... Read More about High prevalence of trypanosomes in European badgers detected using ITS-PCR.

Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii (2015)
Journal Article
Lun, Z., Lai, D., Wen, Y., Zheng, L., Shen, J., Yang, T., …Ayala, F. (2015). Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 112(29), 8835-8842. https://doi.org/10.1073/pnas.1502599112

Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in... Read More about Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.

Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. (2015)
Journal Article
Hide, G. (2015). Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. Parasitology, 142(10), 1348-1349. https://doi.org/10.1017/S0031182015000645

Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia (2015)
Journal Article
Guo, H., Gao, J., Luo, Y., Wen, Y., Zhang, Y., Hide, G., …Lun, Z. (2015). Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proceedings of the National Academy of Sciences, 112(14), 4435-40. https://doi.org/10.1073/pnas.1503474112

The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl(-) secretion system plays a key role in mucociliary clearance of inhaled pathogens. We hav... Read More about Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia.