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All Outputs (6)

Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents (2020)
Thesis
Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound tha... Read More about Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents.

Synthesis and evaluation of novel heterocyclic compounds as anticancer agents (2020)
Thesis
Mal ullah, A. Synthesis and evaluation of novel heterocyclic compounds as anticancer agents. (Thesis). University of Salford

There is a clear need for anti-cancer therapies that have effective cytotoxic efficiency and
marginal toxicity, preferably zero. For this goal, researchers have been persevering to
develop new drugs from natural resources. Among them are agents tha... Read More about Synthesis and evaluation of novel heterocyclic compounds as anticancer agents.

The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products (2020)
Thesis
Omonga, N. The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products. (Thesis). University of Salford

This study focused on isolation, synthesis, development and evaluation of novel antimicrobial and anticancer agents from natural product. Natural products have found lead applications in the pharmaceutical industry as sources of chemotherapeutics aga... Read More about The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products.

Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford

Disruption of protein kinase signalling pathways is often associated with cancer. The
RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers
and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics (2008)
Thesis
Bennett, E. Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics. (Thesis). University of Salford

Protein-protein interactions are essential for all living systems. The interactions
between tubulin dimers is already a broadly studied area, whereas the PDZ domain
interactions is a relatively recent area of study. The literature in these areas is... Read More about Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics.

Synthesis and evaluation of novel antivascular agents for two-photon activation
Thesis
Barnes, N. (in press). Synthesis and evaluation of novel antivascular agents for two-photon activation. (Thesis). University of Salford

Cancer is one of the major causes of death worldwide, hence the development of novel effective treatments to combat this disease is important. Combretastatins are powerful anticancer drugs with some derivatives in advanced clinical trials for cancer... Read More about Synthesis and evaluation of novel antivascular agents for two-photon activation.