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Role of regulatory T-cells in COPD (2010)
Journal Article
Plumb, J., Smyth, L., & Singh, D. (2010). Role of regulatory T-cells in COPD

Chronic Obstructive Pulmonary Disease (COPD) is characterized by progressive and irreversible airflow limitation, caused in most cases by cigarette smoking. Increased CD8 cell numbers are associated with disease progression, and the presence of terti... Read More about Role of regulatory T-cells in COPD.

A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients (2010)
Journal Article
Singh, D., Smyth, L., Borrill, Z., Sweeney, L., & Tal-Singer, R. (2010). A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. Journal of Clinical Pharmacology, 50(1), 94-100. https://doi.org/10.1177/0091270009347873

The p38 mitogen-activated protein kinase (MAPK) signaling upregulates inflammation and is known to be increased in chronic obstructive pulmonary disease (COPD). The authors assessed the pharmacology of the novel p38 MAPK inhibitor SB-681323 using blo... Read More about A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.

Increased airway T regulatory cells in asthmatic subjects (2010)
Journal Article
Smyth, L., Eustace, A., Kolsum, U., Blaikely, J., & Singh, D. (2010). Increased airway T regulatory cells in asthmatic subjects. Chest, 138(4), 905-912. https://doi.org/10.1378/chest.09-3079

Background: T regulatory cells (Tregs) may play a role in the suppression of effector lymphocyte activity in asthma. We hypothesized that Treg numbers would be increased in patients with more severe asthma. We also investigated the regulatory functio... Read More about Increased airway T regulatory cells in asthmatic subjects.

Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients (2010)
Journal Article
Eustace, A., Smyth, L., Mitchell, L., Williamson, K., Plumb, J., & Singh, D. (2010). Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients. Chest, https://doi.org/10.1378/chest.10-0779

Background: Lymphocytes secrete IL-17A and IL-17F which enhance innate immune responses. IL-17 expression has not been studied in COPD small airways. The aim was to quantify IL-17A and IL-17F expression in the peripheral lung tissue of COPD patients... Read More about Identification of cells expressing Interleukin-17A and F in the lungs of COPD patients.