All Outputs (4)

High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo (2024)
Journal Article
Mauro-Lizcano, M., Di Pisa, F., Larrea Murillo, L., Sugden, C. J., Sotgia, F., & Lisanti, M. P. (in press). High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo. Cell Death and Disease, 15(10), Article 745. https://doi.org/10.1038/s41419-024-07103-9

Here, we examined the potential role of mitochondrial DNA (mtDNA) levels in conveying aggressive phenotypes in cancer cells, using two widely-used breast cell lines as model systems (MCF7[ER+] and MDA-MB-231[ER-]). These human breast cancer cell line... Read More about High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo.

In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods (2024)
Journal Article
Tóth, F., Moftakhar, Z., Sotgia, F., & Lisanti, M. P. (in press). In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods. Cells, 13(10), 841. https://doi.org/10.3390/cells13100841

Although cellular senescence was originally defined as an irreversible form of cell cycle arrest, in therapy-induced senescence models, the emergence of proliferative senescence-escaped cancer cells has been reported by several groups, challenging th... Read More about In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods.

Role of Mitochondrial DNA Polymerase gamma (POLG) in Breast Cancer (2024)
Thesis
Chinigo, C. (2024). Role of Mitochondrial DNA Polymerase gamma (POLG) in Breast Cancer. (Thesis). University of Salford

Breast cancer is the most frequent malignancy in women and represents one of the driving
causes of death from cancer, worldwide. In this scenario, targeUng tumor heterogeneity
could present important therapeuUcal implicaUons. Indeed, neoplasUc brea... Read More about Role of Mitochondrial DNA Polymerase gamma (POLG) in Breast Cancer.

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. (2024)
Journal Article
Wolfe, A. R., Cui, T., Baie, S., Corrales-Guerrero, S., Webb, A., Castro-Aceituno, V., …Lisanti, M. (2024). Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. Science Advances, 10(9), eadj3551. https://doi.org/10.1126/sciadv.adj3551

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its nutrient-scavenging ability, crucial for tumor progression. Here, we investigated the roles of caveolae-mediated endocytosis (CME) in PDAC progression. Analysis of patient data across di... Read More about Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions..