All Outputs (4)

CCR5 receptor antagonists block metastasis to bone of v-Src Oncogene-Transformed Metastatic prostate cancer cell lines (2014)
Journal Article
Sicoli, D., Jiao, X., Ju, X., Velasco-Velazquez, M., Ertel, A., Addya, S., …Pestell, R. (2014). CCR5 receptor antagonists block metastasis to bone of v-Src Oncogene-Transformed Metastatic prostate cancer cell lines. Cancer Research, 74(23), 7103-7114. https://doi.org/10.1158/0008-5472.CAN-14-0612

Src family kinases (SFK) integrate signal transduction for multiple receptors, regulating cellular proliferation, invasion, and metastasis in human cancer. Although Src is rarely mutated in human prostate cancer, SFK activity is increased in the majo... Read More about CCR5 receptor antagonists block metastasis to bone of v-Src Oncogene-Transformed Metastatic prostate cancer cell lines.

Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggre... Read More about Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth.

CAPER, a novel regulator of human breast cancer progression (2014)
Journal Article
Mercier, I., Gonzales, D., Quann, K., Pestell, T., Molchansky, A., Sotgia, F., …Jasmin, J. (2014). CAPER, a novel regulator of human breast cancer progression. Cell Cycle, 13(8), 1256-1264. https://doi.org/10.4161/cc.28156

CAPE R is an estrogen receptor (ER) co-activator that was recently shown to be involved in human breast cancer pathogenesis. Indeed, we reported increased expression of CAPE R in human breast cancer specimens. We demonstrated that CAPE R was undete... Read More about CAPER, a novel regulator of human breast cancer progression.

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Lisanti, M., & Sotgia, F. (2014). Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Seminars in Cancer Biology, 25, 47-60. https://doi.org/10.1016/j.semcancer.2014.01.005

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and metastasis, driving chemotherapy resistance and poor clinical outcome. Th... Read More about Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.