All Outputs (9)

Mitochondrial Fission Factor (MFF) inhibits mitochondrial metabolism and reduces breast cancer stem cell (CSC) activity (2020)
Journal Article
Sánchez-Alvarez, R., De Francesco, E., Fiorillo, M., Sotgia, F., & Lisanti, M. (2020). Mitochondrial Fission Factor (MFF) inhibits mitochondrial metabolism and reduces breast cancer stem cell (CSC) activity. Frontiers in Oncology, 10, 1776. https://doi.org/10.3389/fonc.2020.01776

Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression. Therefore, interfering with mitochondria biology and function may be regarded... Read More about Mitochondrial Fission Factor (MFF) inhibits mitochondrial metabolism and reduces breast cancer stem cell (CSC) activity.

Using the common cold virus as a naturally occurring vaccine to prevent COVID-19 : lessons from Edward Jenner (2020)
Journal Article
Sotgia, F., & Lisanti, M. (2020). Using the common cold virus as a naturally occurring vaccine to prevent COVID-19 : lessons from Edward Jenner. Aging, 12(19), 18797-18803. https://doi.org/10.18632/aging.104166

Three recent papers published in Nature, Science and Cell, all present clear evidence that there is cross-reactive T-cell immunity between human coronaviruses (229E, NL63, OC43, and HKU1), linked with the common cold, and SARS-CoV-2, the causative ag... Read More about Using the common cold virus as a naturally occurring vaccine to prevent COVID-19 : lessons from Edward Jenner.

The membrane-associated form of cyclin D1 enhances cellular invasion (2020)
Journal Article
Chen, K., Jiao, X., Ashton, A., Di Rocco, A., Pestell, T., Sun, Y., …Pestell, R. (2020). The membrane-associated form of cyclin D1 enhances cellular invasion. Oncogenesis, 9, 83. https://doi.org/10.1038/s41389-020-00266-y

The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression. In addition to the nucleus, herein cyc... Read More about The membrane-associated form of cyclin D1 enhances cellular invasion.

A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity (2020)
Journal Article
Ozsvari, B., Magalhaes, L., Latimer, J., Kangasmetsa, J., Sotgia, F., & Lisanti, M. (2020). A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity. Frontiers in Oncology, 10, 1528. https://doi.org/10.3389/fonc.2020.01528

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analogue, a myristic acid (14 carbon) moiety is covalently attached t... Read More about A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity.

Cholesterol and mevalonate : two metabolites involved in breast cancer progression and drug resistance through the ERRα pathway (2020)
Journal Article
Brindisi, M., Fiorillo, M., Frattaruolo, L., Sotgia, F., Lisanti, M., & Cappello, A. (2020). Cholesterol and mevalonate : two metabolites involved in breast cancer progression and drug resistance through the ERRα pathway. Cells, 9(8), e1819. https://doi.org/10.3390/cells9081819

Breast cancer is the second greatest cause of cancer-related death in women. Resistance to endocrine treatments or chemotherapy is a limiting drawback. In this context, this work aims to evaluate the effects of cholesterol and mevalonate during tumor... Read More about Cholesterol and mevalonate : two metabolites involved in breast cancer progression and drug resistance through the ERRα pathway.

Essential role of STAT5a in DCIS formation and invasion following estrogen treatment (2020)
Journal Article
Dees, S., Pontiggia, L., Jasmin, J., Sotgia, F., Lisanti, M., & Mercier, I. (2020). Essential role of STAT5a in DCIS formation and invasion following estrogen treatment. Aging, 12(14), 15104-15120. https://doi.org/10.18632/aging.103586

Ductal carcinoma in situ (DCIS) is one of the earliest stages of breast cancer (BCa). The mechanisms by which DCIS lesions progress to an invasive state while others remain indolent are yet to be fully characterized and both diagnosis and treatment o... Read More about Essential role of STAT5a in DCIS formation and invasion following estrogen treatment.

Deferiprone (DFP) targets cancer stem cell (CSC) propagation by inhibiting mitochondrial metabolism and inducing ROS production (2020)
Journal Article
Fiorillo, M., Tóth, F., Brindisi, M., Sotgia, F., & Lisanti, M. (2020). Deferiprone (DFP) targets cancer stem cell (CSC) propagation by inhibiting mitochondrial metabolism and inducing ROS production. Cells, 9(6), e1529. https://doi.org/10.3390/cells9061529

Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major. As iron is a critical factor in Fe-S cluster assembly... Read More about Deferiprone (DFP) targets cancer stem cell (CSC) propagation by inhibiting mitochondrial metabolism and inducing ROS production.

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis : mitoriboscins and TPP compounds (2020)
Journal Article
Ozsvari, B., Sotgia, F., & Lisanti, M. (2020). First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis : mitoriboscins and TPP compounds. Aging, 12(11), 10162-10179. https://doi.org/10.18632/aging.103336

Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence, distant metastasis and drug-resistance, in the vast majority of cancer patients. Therefore, there is an urgent need to identify new drugs that can target and eradicat... Read More about First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis : mitoriboscins and TPP compounds.

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? (2020)
Journal Article
Sargiacomo, C., Sotgia, F., & Lisanti, M. (2020). COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?. Aging, 12(8), 6511-6517. https://doi.org/10.18632/aging.103001

COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family. COVID-19 originated in China and spread world-wide, resulting in the p... Read More about COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?.