Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy
(2017)
Journal Article
Ozsvari, B., Bonuccelli, G., Sanchez-Alvarez, R., Foster, R., Sotgia, F., & Lisanti, M. (2017). Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy. Aging, 9(12), 2610-2628. https://doi.org/10.18632/aging.101351
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or no toxic side... Read More about Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration : vitamin B2 (Riboflavin) in cancer therapy.