All Outputs (2)

A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores (2015)
Journal Article
Fois, G., Hobi, N., Felder, E., Ziegler, A., Miklavc, P., Walther, P., …Dietl, P. (2015). A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores. Cell Calcium, 58(6), 628-637. https://doi.org/10.1016/j.ceca.2015.10.002

Ambroxol (Ax) is a frequently prescribed drug used to facilitate mucociliary clearance, but its mode of action is yet poorly understood. Here we show by X-ray spectroscopy that Ax accumulates in lamellar bodies (LBs), the surfactant storing, secretor... Read More about A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores.

Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles (2015)
Journal Article
Miklavc, P., Ehinger, K., Sultan, A., Felder, T., Paul, P., Gottschalk, K., & Frick, M. (2015). Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles. Journal of Cell Science, 128(6), 1193-1203. https://doi.org/10.1242/jcs.165571

In many secretory cells actin and myosin are specifically recruited to the surface of secretory granules following their fusion with the plasma membrane. Actomyosin-dependent compression of fused granules is essential to promote active extrusion of c... Read More about Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles.