FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis
(2018)
Journal Article
Ponnusamy, A., Sinha, S., Hyde, G. D., Borland, S. J., Taylor, R. F., Pond, E., …Canfield, A. E. (2018). FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis. PloS one, 13(4), Article e0196232. https://doi.org/10.1371/journal.pone.0196232
Background
Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This...
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